Ruqian Zhao Selected Research

Betaine (C.B.B.)

5/2020	Fetal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in offspring cockerels with modification of promoter DNA methylation.
4/2018	Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
1/2018	Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
1/2018	Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
12/2017	Dietary betaine supplementation increases adrenal expression of steroidogenic acute regulatory protein and yolk deposition of corticosterone in laying hens.
6/2017	Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
1/2017	In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications.
10/2015	Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
1/2015	In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.

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Ruqian Zhao Research Topics

Disease

22	Body Weight (Weight, Body) 05/2020 - 09/2007
12	Inflammation (Inflammations) 11/2021 - 12/2013
9	Obesity 12/2021 - 06/2009
6	Non-alcoholic Fatty Liver Disease 06/2022 - 01/2018
5	Fatty Liver 12/2021 - 01/2017
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 01/2016
4	Insulin Resistance 01/2019 - 06/2011
4	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2016 - 03/2013
3	Infections 04/2019 - 05/2016
2	Fibrosis (Cirrhosis) 12/2020 - 01/2020
2	Neoplasms (Cancer) 10/2019 - 06/2018
2	Muscular Atrophy (Muscle Atrophy) 01/2018 - 01/2018
2	Glucose Intolerance 02/2017 - 10/2015
2	Choriocarcinoma 11/2016 - 01/2016
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 11/2016 - 05/2012
2	Malnutrition (Nutritional Deficiencies) 09/2015 - 01/2013
2	Necrosis 03/2015 - 02/2011
1	Dosage-sensitive sex reversal 06/2022
1	Liver Diseases (Liver Disease) 12/2021
1	Hypoxia (Hypoxemia) 12/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021
1	Dysbiosis 01/2021
1	Triple Negative Breast Neoplasms 10/2019
1	Breast Neoplasms (Breast Cancer) 10/2019
1	Starvation 04/2018
1	Muscular Diseases (Myopathy) 01/2018
1	Hyperglycemia 01/2018
1	Metabolic Diseases (Metabolic Disease) 01/2017
1	Pathologic Processes 01/2017
1	Hyperhomocysteinemia 10/2016

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2011
9	Betaine (C.B.B.)FDA Link 05/2020 - 01/2015
9	CholesterolIBA 05/2020 - 01/2012
7	Messenger RNA (mRNA)IBA 12/2021 - 10/2011
6	CorticosteroneIBA 12/2021 - 03/2013
6	GlucocorticoidsIBA 01/2020 - 10/2014
5	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 06/2022 - 03/2010
5	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 11/2016
5	Triglycerides (Triacylglycerol)IBA 07/2018 - 10/2014
5	LeptinIBA 01/2017 - 04/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 06/2011
4	Insulin (Novolin)FDA Link 06/2018 - 06/2011
4	LipopolysaccharidesIBA 04/2017 - 12/2013
4	Butyrates (Butyrate)IBA 02/2017 - 08/2016
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 06/2022 - 01/2017
3	6-methyladenineIBA 12/2021 - 01/2020
3	RNA (Ribonucleic Acid)IBA 11/2021 - 04/2016
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2013
3	Butyric Acid (Butanoic Acid)IBA 01/2019 - 01/2017
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2018 - 03/2014
3	LipidsIBA 02/2017 - 10/2015
2	IronIBA 06/2022 - 11/2018
2	Mitochondrial DNA (mtDNA)IBA 01/2019 - 01/2013
2	Blood Glucose (Blood Sugar)IBA 10/2018 - 10/2015
2	Amino Acids FDA Link 04/2018 - 01/2016
2	Adenosine Triphosphate (ATP)IBA 01/2017 - 03/2014
2	Insulin-Like Growth Factor I (IGF-1)IBA 11/2016 - 04/2003
2	Oxidoreductases (Dehydrogenase)IBA 09/2015 - 05/2012
2	CytokinesIBA 03/2015 - 02/2011
1	N-methyladenosineIBA 12/2021
1	Long Noncoding RNAIBA 12/2021
1	angiogeninIBA 11/2021
1	Ribonucleases (Ribonuclease)IBA 11/2021
1	Transfer RNA (tRNA)IBA 11/2021
1	GlycolipidsIBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021
1	Insulin-Like PeptidesIBA 12/2020
1	Carbon Tetrachloride (Tetrachloromethane)IBA 12/2020
1	MitogensIBA 12/2020
1	Cholesterol Esters (Cholesteryl Esters)IBA 05/2020
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2020
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 11/2019
1	Estrogen ReceptorsIBA 10/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2019
1	Hormones (Hormone)IBA 04/2019
1	EnzymesIBA 01/2019
1	AntioxidantsIBA 01/2019
1	12S ribosomal RNAIBA 01/2019
1	16S Ribosomal RNAIBA 01/2019
1	N-(3-oxododecanoyl)homoserine lactoneIBA 01/2019
1	MethyltransferasesIBA 01/2019
1	CaspasesIBA 01/2019
1	Histone Deacetylase 1IBA 07/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2018
1	Histones (Histone)IBA 07/2018
1	Iodide Peroxidase (Deiodinase)IBA 04/2018
1	Thyroid HormonesIBA 04/2018
1	SpermidineIBA 01/2018
1	SolventsIBA 01/2018
1	Ethanol (Ethyl Alcohol)IBA 01/2018
1	F-Box ProteinsIBA 01/2018
1	AlbuminsIBA 04/2017
1	CreatinineIBA 04/2017
1	Biomarkers (Surrogate Marker)IBA 04/2017
1	Volatile Fatty AcidsIBA 02/2017
1	Liver X ReceptorsIBA 01/2017
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 01/2017
1	AcidsIBA 10/2016

Therapy/Procedure

2	Oral Administration 01/2017 - 08/2016
1	Protein-Restricted Diet (Diet, Protein Restricted) 04/2018